Dogoxin

DIGOXIN Indication:Atrial Fibrillation Normal treat: consignment: 0.25mg every 2 hours IV or PO (max dose=1.5mg) maintenance: 0.125mg-0.375mg PO 0.125-0.25mg IV Geriatrics > 70yrs with good nephritic function should be smashed with 0.5mg x2 doses and maintained with 0.125mg PO once daily. The patient in this fictitious character is a 72yo who was presumptuousness 0.5mg IV two hours apart (instead of the recommended half a dozen hours apart) with a maintenance dose of 0.125mg daily. Therapeutic serum bollix up=0.8-2ng/mL Time to peak= 1-3 hours T ½= 1.5-2 days next the two fill doses, the patient had a digoxin make of 1.5ng/mL. Two days, and two doses later, the patient was bradycardic and hypotensive with a digoxin level of 1.9ng/mL. digoxin was stopped and after 15 hours the digoxin level dropped to 1.2ng/mL. digoxin works by inhibiting Na+/K+ ATPase, which causes and increase in intracellular Na+ concentration and tolerate running t o hyperkalemia and hypercalcemia. This in turn can lead to archaean afterdepolarization, cardiac irritability, and dysrhythmias. As vagal sapidity increases and sympathetic tone decreases it can lead to bradycardia and heartblock.

The most common symptoms of digoxin perniciousness are: slap-upnausea, vomiting, abdominal pain, lethargy, bradycardia Chronicbradycardia, malaise, nausea, anorexia, delirium, vision changes sedatebradycardia, heartblock, vomiting, shock, hyperkalemia If potassium level is > 5mEq/L with symptomatic bradycardia, digoxin toxicity should be hardened with Digoxin Immune Fab, which works by binding di goxin molecules and helps to eliminate them ! from the body. Each vial of DIGIBIND provide bind with 0.5mg of digoxin. References: Micromedex dose education App Thomson Reuters Goodman and Gilmans DIGIBIND Drug Information Leaflet McGraw Hill Diagnosis and TreatmentIf you privation to get a full essay, order it on our website: BestEssayCheap.com

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